Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water

In this work, an analytical method based on solid phase extraction (SPE) and liquid chromatography tandem mass spectrometry (LC-APCI-MS/MS) was developed and validated for the determination and confirmation of five pharmaceuticals in water samples. The limits of detection (LOD) ranged from 0.053 to...

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Bibliographic Details
Published in:Journal of the Brazilian Chemical Society 2011-10, Vol.22 (10), p.1944-1952
Main Authors: Cardoso, Liziane V., Tomasini, Débora, Sampaio, Maicon R. F., Caldas, Sergiane S., Kleemann, Natiele, Primel, Ednei G., Gonçalves, Fabio F.
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
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Summary:In this work, an analytical method based on solid phase extraction (SPE) and liquid chromatography tandem mass spectrometry (LC-APCI-MS/MS) was developed and validated for the determination and confirmation of five pharmaceuticals in water samples. The limits of detection (LOD) ranged from 0.053 to 0.53 µg L-1 and the limits of quantification (LOQ) from 0.16 to 1.6 µg L-1. Good linearity was obtained with r > 0.99 for all compounds. The recoveries of the compounds ranged from 70 to 120% with relative standard deviations (RSD) below 20% for all. Through multiple reactions monitoring (MRM) two different transitions, precursor ion-product ion, were selected for each pharmaceutical.
ISSN:0103-5053
1678-4790
DOI:10.1590/S0103-50532011001000016