Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts

It is reported the synthesis of 24 Morita-Baylis-Hillman adducts (3a-3l/6a-6l) using microwave irradiation at 80 ºC or conventional protocol at 0 ºC to promote the reactions between aromatic aldehydes and methyl acrylate or acrylonitrile (81-99%). It is shown that the reaction of 2-hydroxy(4-bromoph...

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Bibliographic Details
Published in:Journal of the Brazilian Chemical Society 2011-11, Vol.22 (11), p.2220-2224
Main Authors: Junior, Claudio G. L., Silva, Fábio P. L., Oliveira, Ramon G. de, Subrinho, Fernanda L., Andrade, Natália G. de, Vasconcellos, Mário L. A. A.
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
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Summary:It is reported the synthesis of 24 Morita-Baylis-Hillman adducts (3a-3l/6a-6l) using microwave irradiation at 80 ºC or conventional protocol at 0 ºC to promote the reactions between aromatic aldehydes and methyl acrylate or acrylonitrile (81-99%). It is shown that the reaction of 2-hydroxy(4-bromophenyl)methyl acrylate formation is reversible at 120 ºC.
ISSN:0103-5053
1678-4790
DOI:10.1590/S0103-50532011001100028