Caavuranamide, a novel steroidal alkaloid from the ripe fruits of Solanum caavurana Vell. (Solanaceae)

Phytochemical investigation of the ripe fruits of Solanum caavurana Vell. (Solanaceae) afforded a novel steroidal alkaloid with spirosolane-type skeleton, named as caavuranamide, together with the alkaloids 4-tomatiden-3-one and 5α-tomatidan-3-one. Their structures were elucidated on the basis of sp...

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Bibliographic Details
Published in:Journal of the Brazilian Chemical Society 2012-02, Vol.23 (2), p.361-366
Main Authors: Vaz, Nelissa Pacheco, Costa, Emmanoel V., Santos, Érica L., Mikich, Sandra Bos, Marques, Francisco A., Braga, Raquel M., Delarmelina, Camila, Duarte, Marta C. T., Ruiz, Ana Lúcia T. G., Souza, Vanessa H. S., Carvalho, João E. de, Maia, Beatriz H. L. N. Sales
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
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Summary:Phytochemical investigation of the ripe fruits of Solanum caavurana Vell. (Solanaceae) afforded a novel steroidal alkaloid with spirosolane-type skeleton, named as caavuranamide, together with the alkaloids 4-tomatiden-3-one and 5α-tomatidan-3-one. Their structures were elucidated on the basis of spectroscopic methods. The antiproliferative and antimicrobial activities for the ethanolic extract, sub-fractions obtained from partition and acid-base treatment were also evaluated. Caavuranamide showed antibacterial activity similar to the chloramphenicol positive control against Rhodococcus equi.
ISSN:0103-5053
1678-4790
DOI:10.1590/S0103-50532012000200025