Grafting Amino Drugs to Poly(styrene- alt -maleic Anhydride) as a Potential Method for Drug Release

Drug delivery systems based on polymer-drug conjugates give an improved treatment with lower toxicity or side effects and be used for the treatment of different diseases. Conjugates of biodegradable poly(styrene-alt-maleic anhydride) (PSMA), with a therapeutic agents such as amantadine hydrochloride...

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Bibliographic Details
Published in:Journal of the Brazilian Chemical Society 2013-07, Vol.24 (7), p.1109-1115
Main Authors: Khazaei, Ardeshir, Saednia, Shahnaz, Saien, Javad, Kazem-Rostami, Masoud, Sadeghpour, Mahdieh, Borazjani, Maryam Kiani, Abbasi, Fatemeh
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
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Summary:Drug delivery systems based on polymer-drug conjugates give an improved treatment with lower toxicity or side effects and be used for the treatment of different diseases. Conjugates of biodegradable poly(styrene-alt-maleic anhydride) (PSMA), with a therapeutic agents such as amantadine hydrochloride, amlodipine, gabapentin, zonisamide and mesalamine, were afforded by the formation of the amide bonds of the amino drugs that reacted with the PSMA anhydride groups. The amounts of covalently conjugated drugs were determined by a¹ H NMR spectroscopic method, and the in vitro release rate in buffer solution (pH 1.3) was studied at body temperature 37 ºC. In kinetic studies, different dissolution models were examined to obtain drug release data and the collected data were well-fitted to the Korsmeyer-Peppas equation, revealing a dominant Fickian diffusion mechanism for drug release under the in vitro conditions.
ISSN:0103-5053
1678-4790
DOI:10.5935/0103-5053.20130145