Prenylated Flavone from Roots of a Hybrid between Artocarpus heterophyllus and Artocarpus integer and its Biological Activities

One new prenylated flavone, 2,8-dihydroxy-3,10-dimethoxy-6-(2-methyl-1-propen-1-yl)-6H,7H-[1]benzopyrano[4,3-b][1]-benzopyran-7-one, together with 24 known compounds were isolated from crude acetone extract from the roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer. Their str...

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Bibliographic Details
Published in:Journal of the Brazilian Chemical Society 2013-10, Vol.24 (10), p.1656-1661
Main Authors: Panthong, Kanda, Tohdee, Kanogwan, Hutadilok-Towatana, Nongporn, Voravuthikunchai, Supayang P., Chusri, Sasitorn
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
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Summary:One new prenylated flavone, 2,8-dihydroxy-3,10-dimethoxy-6-(2-methyl-1-propen-1-yl)-6H,7H-[1]benzopyrano[4,3-b][1]-benzopyran-7-one, together with 24 known compounds were isolated from crude acetone extract from the roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer. Their structures were determined by 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data. The antioxidant and antibacterial activities of the isolated compounds were evaluated. The new compound showed potent antioxidant activity against DPPH• and superoxide with IC50 values of 0.033 and 0.125 mg mL-1, respectively. Significant antibacterial activity against Acinetobacter baumannii was observed with MIC value of 50 mg mL-1.
ISSN:0103-5053
1678-4790
DOI:10.5935/0103-5053.20130212