Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems

Packed bed reactors can be used as an interesting alternative on the bioreduction of β-ketoesteres mediated by immobilized microorganisms. Here in, we report our results on the bioreduction of ethyl 3-oxohexanoate by immobilized Kluyveromyces marxianus cells and tert-butyl 3-oxobutanoate by immobili...

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Bibliographic Details
Published in:Journal of the Brazilian Chemical Society 2015-03, Vol.26 (3), p.550-554
Main Authors: Lopes, Raquel O., Grimm, Simon, Ribeiro, Joyce B., Leal, Ivana C. R., Miranda, Leandro S. M., Souza, Rodrigo O. M. A. de
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
Online Access:Get full text
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Summary:Packed bed reactors can be used as an interesting alternative on the bioreduction of β-ketoesteres mediated by immobilized microorganisms. Here in, we report our results on the bioreduction of ethyl 3-oxohexanoate by immobilized Kluyveromyces marxianus cells and tert-butyl 3-oxobutanoate by immobilized Rhodotorula rubra cells under continuous flow conditions leading the desired β-hydroxy esters corresponding in high yields and enantiomeric excess.
ISSN:0103-5053
1678-4790
DOI:10.5935/0103-5053.20150009