Synthesis and Antifungal Activity Against Candida Strains of Mesoionic System Derived From 1,3-Thyazolium-5-thiolate

A series of ten new compounds have been synthetized in satisfactory yields (85-95%) through the treatment of isopropyl mesoionic 1,3-thiazolium-5-thiolate with 2-chloro-N-arylacetamides and characterized by elemental analysis, infrared (IR), 1H and 13C nuclear magnetic resonance (NMR) spectroscopies...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Brazilian Chemical Society 2016-10, Vol.27 (10), p.1807-1813
Main Authors: Peixoto, Isabelle N., Souza, Helivaldo D. S., Lira, Bruno F., Silva, Daniele F., Lima, Edeltrudes O., Barbosa-Filho, José M., Athayde-Filho, Petrônio F. de
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of ten new compounds have been synthetized in satisfactory yields (85-95%) through the treatment of isopropyl mesoionic 1,3-thiazolium-5-thiolate with 2-chloro-N-arylacetamides and characterized by elemental analysis, infrared (IR), 1H and 13C nuclear magnetic resonance (NMR) spectroscopies. The newly synthesized compounds were evaluated as new drug candidates in in silico study and for their antifungal activity against several strains of Candida albicans. In silico study indicates that no compound has potential to be a new drug while four compounds showed medium to strong activity with minimum inhibitory concentration (MIC) range of 256-1024 µg mL-1.
ISSN:0103-5053
1678-4790
DOI:10.5935/0103-5053.20160063