Synthesis and Evaluation of Nematicidal Activity of Compounds Derived from Norbornadiene

Nematode is a major problem in agriculture, the effective way to control this pest is through chemical control, but the efficient molecules present in the market have great toxicity to mammals and birds. Thus, there is a constant demand for the development of new nematicide molecules. This study des...

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Bibliographic Details
Published in:Journal of the Brazilian Chemical Society 2020-09, Vol.31 (9), p.1805-1814
Main Authors: Gomes, Anni, Demuner, Antonio, Alvarenga, Elson, Gondim, João, Fonseca, Andressa, Buonicontro, Dalila, Pilau, Eduardo, Silva, Evandro
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
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Summary:Nematode is a major problem in agriculture, the effective way to control this pest is through chemical control, but the efficient molecules present in the market have great toxicity to mammals and birds. Thus, there is a constant demand for the development of new nematicide molecules. This study describes the synthesis of 21 novel esters derived from norbornadiene and evaluation of their potential activity against Meloidogyne javanica. The esters 5-25 presented 50% mortality of the nematodes. The acid 3 and the ester 4 caused 96 and 93% mortality of the nematodes, respectively. The lethal concentration to kill 50% of the nematodes (LD50) were determined as being 11.8 µg mL-1 for the acid 3 and 99.4 µg mL-1 for the ester 4. According to the results obtained it is believed that polarity seems to be a key factor for the higher activity of compound 3 compared to structurally similar ester derivatives.
ISSN:0103-5053
1678-4790
DOI:10.21577/0103-5053.20200067