The Versatility of Two-Dimensional Liquid Chromatography

This review deals with two-dimensional liquid chromatography (2D-LC) separations encompassing target heart-cut (LC-LC), multiple heart-cut (mLC-LC), non-targeted comprehensive (LC × LC), and selective comprehensive (sLC × LC) analysis. It presents an overview of basic concepts and emphasizes the ver...

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Bibliographic Details
Published in:Journal of the Brazilian Chemical Society 2023-11, Vol.34 (11), p.1565-1580
Main Authors: Cardoso, Carmen, de Moraes, Marcela, Cass, Quezia
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
Online Access:Get full text
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Summary:This review deals with two-dimensional liquid chromatography (2D-LC) separations encompassing target heart-cut (LC-LC), multiple heart-cut (mLC-LC), non-targeted comprehensive (LC × LC), and selective comprehensive (sLC × LC) analysis. It presents an overview of basic concepts and emphasizes the versatility of the applications gained by going from one-(1D) to two-dimensional (2D) separations. This review also discusses target analysis of achiral and chiral drugs for different applications and the use of 2D-LC in zonal bioaffinity chromatography. Advances in instrumental and column technologies have widened the application of LC × LC and sLC × LC separations, and we will discuss some of them.
ISSN:0103-5053
1678-4790
DOI:10.21577/0103-5053.20230118