The Versatility of Two-Dimensional Liquid Chromatography

This review deals with two-dimensional liquid chromatography (2D-LC) separations encompassing target heart-cut (LC-LC), multiple heart-cut (mLC-LC), non-targeted comprehensive (LC × LC), and selective comprehensive (sLC × LC) analysis. It presents an overview of basic concepts and emphasizes the ver...

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Published in:Journal of the Brazilian Chemical Society 2023-11, Vol.34 (11), p.1565-1580
Main Authors: Cardoso, Carmen, de Moraes, Marcela, Cass, Quezia
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Language:English
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CHEMISTRY, MULTIDISCIPLINARY
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Cass, Quezia
description This review deals with two-dimensional liquid chromatography (2D-LC) separations encompassing target heart-cut (LC-LC), multiple heart-cut (mLC-LC), non-targeted comprehensive (LC × LC), and selective comprehensive (sLC × LC) analysis. It presents an overview of basic concepts and emphasizes the versatility of the applications gained by going from one-(1D) to two-dimensional (2D) separations. This review also discusses target analysis of achiral and chiral drugs for different applications and the use of 2D-LC in zonal bioaffinity chromatography. Advances in instrumental and column technologies have widened the application of LC × LC and sLC × LC separations, and we will discuss some of them.
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title The Versatility of Two-Dimensional Liquid Chromatography
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