Cybernetic structured modeling of the production of polyhydroxyalkanoates by Alcaligenes Eutrophus

This paper presents a cybernetic structured mathematical model developed for the fermentation step of the process of production of the copolymer of polyhydroxyalkanoates by the bacteria Alcaligenes eutrophus. This process is performed in two different fermentation stages. The first emphasizes the gr...

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Bibliographic Details
Published in:Brazilian journal of chemical engineering 1999-06, Vol.16 (2), p.205-212
Main Authors: FERRAZ, L., BONOMI, A., PICCOLI, R. A. M., KAPRITCHKOFF, F. M., SCHMIDELL, W., ALLI, R. C. P., TAKANO, C. Y., MATTOS, M. N., OLIVEIRA, V., FONTOLAN, V.
Format: Article
Language:English
Subjects:
Animal cell culture
Bacteria
ENGINEERING, CHEMICAL
Enzyme inhibition
Enzymes
Fermentation
Mathematical models
Nitrogen
Substrates
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Summary:This paper presents a cybernetic structured mathematical model developed for the fermentation step of the process of production of the copolymer of polyhydroxyalkanoates by the bacteria Alcaligenes eutrophus. This process is performed in two different fermentation stages. The first emphasizes the growth of the microorganism in a batch operation without substrates limitations, while in the second, the focus is on copolymer production by a fed-batch operation in the absence of the nitrogen source. This paper presents the results of the treatment of experimental data and of preliminary parameter estimation. The fitting of the proposed model to the experimental data of a standard experiment showed a good agreement.
ISSN:0104-6632
1678-4383
0104-6632
DOI:10.1590/S0104-66321999000200014