Gongronema latifolium Modulates Rauwolfia vomitoria-Induced Behaviour and Histomorphology of the Cerebral Cortex

Rauwolfia vomitoria (RV) has potent sedative effect, which may result in severe unpleasant consequences if not controlled. This necessitated this study on the effect of Gongronema latifolium (GL) on RV-induced behaviour, biochemical activities, and histomorphology of the cerebral cortex. Eighteen ma...

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Bibliographic Details
Published in:International journal of morphology 2015-03, Vol.33 (1), p.77-84
Main Authors: Ekong, Moses B, Peter, Aniekan I, Ekpene, Ubong U, Bassey, Enobong I, Eluwa, Mokutima A, Akpanabiatu, Monday I, Ekanem, Theresa B
Format: Article
Language:English
Subjects:
ANATOMY & MORPHOLOGY
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Summary:Rauwolfia vomitoria (RV) has potent sedative effect, which may result in severe unpleasant consequences if not controlled. This necessitated this study on the effect of Gongronema latifolium (GL) on RV-induced behaviour, biochemical activities, and histomorphology of the cerebral cortex. Eighteen male Wistar rats of average weight 266 g were grouped into three (13). Group 1 was the control administered 0.5 mL of Tween®20, while groups 2 and 3 were administered 150 mg/kg of RV, and a combination of 150 mg/kg of RV and 200 mg/kg of GL (RV+GL), respectively for seven days. Twelve hours after treatments, open field neurobehavioral test was carried-out and the animals euthanized. Their sera were analyzed, and their cerebral cortices routinely processed by H&E method. There was lower (p
ISSN:0717-9502
0717-9502
DOI:10.4067/S0717-95022015000100013