Effects of Xylene on Respiratory Mucosa in Rats

In this study we examined the effects histopathologic and immunohistochemical of xylene inhalation in rats by using light microscopy. Adult wistar albino rats were used in this study. Eight rats were in control group and 8 rats were in the experimental group. The experimental group was exposed to 30...

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Bibliographic Details
Published in:International journal of morphology 2016-09, Vol.34 (3), p.934-938
Main Authors: Arslan, Eda, Samanci, Baver, Samanci, Bölükbasi Seyla, Özevren, Hüseyin, Deveci, E
Format: Article
Language:English
Subjects:
ANATOMY & MORPHOLOGY
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Summary:In this study we examined the effects histopathologic and immunohistochemical of xylene inhalation in rats by using light microscopy. Adult wistar albino rats were used in this study. Eight rats were in control group and 8 rats were in the experimental group. The experimental group was exposed to 300 ppm formaldehyde 35 min/day, 5 days/week for 8 weeks. The lining epithelium of respiratory mucosa showed a loss of ciliated cells with metaplasia of goblet cells, hyperplasia of squamous cells and edema, inflamation in sub epithelial area). In the group treated xylene. Disruption of cell-cell contact was observed. Weak expression of E-cadherin was observed between cells. The vascular endothelium of capillaries and venoles showed intense immunostaining for VEGF.
ISSN:0717-9502
0717-9502
DOI:10.4067/S0717-95022016000300019