The Morphology of Paca (Cuniculus paca) Testis with High Dose of Letrozole an Aromatase Inhibitor

The study reported the influence of the high and acute dose of Letrozole on the testis morphology in paca (Cuniculus paca), an aromatase inhibitor that reduces the endogenous estrogen, the essential hormone for spermatogenesis. Morphological changes were observed in seminiferous epithelium with germ...

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Bibliographic Details
Published in:International journal of morphology 2020-12, Vol.38 (6), p.1525-1527
Main Authors: Simões, Luciana Senna, Sasahara, Taís Harumi de Castro, Favaron, Phelipe Oliveira, Leal, Leonardo Martins, Oliveira, Fabrício Singaretti de, Fratini, Paula, Berger, Trish, Machado, Marcia Rita Fernandes, Miglino, Maria Angélica
Format: Article
Language:English
Subjects:
ANATOMY & MORPHOLOGY
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Summary:The study reported the influence of the high and acute dose of Letrozole on the testis morphology in paca (Cuniculus paca), an aromatase inhibitor that reduces the endogenous estrogen, the essential hormone for spermatogenesis. Morphological changes were observed in seminiferous epithelium with germ cells with apoptotic characteristics and presence of vacuoles and nuclei in pycnose.
ISSN:0717-9502
0717-9502
DOI:10.4067/S0717-95022020000601525