Changes in Cardiac Morphology and Visceral Fat After the Use of Testosterone Associated with Aerobic Exercise in Wistar Rats Induced Diabetes

• Published in: International journal of morphology 2024-10, Vol.42 (5), p.1216-1221
• Main Authors: Perroni-Kudiess, Jéssica, Freitas-da-Silva, Carolina, de-Oliveira-Souza, Rebeca Ferreira, de-Carvalho-Barros, Roseamely Angelica, de-Abreu, Luiz Carlos, Magalhães-Neto, Anibal Magalhaes, Oliveira-Gonçalves, Luis Carlos, Balbino-Lizardo, Frederico, Montes-Fidale, Thiago, Silva, Luípa Michele, Magalhães-de-Abreu, Rusleyd Maria, Martins-Silva, Romeu Paulo
• Format: Article
• Language: eng ; por
• Subjects: ANATOMY & MORPHOLOGY
• ISSN: 0717-9502; 0717-9502
• DOI: 10.4067/S0717-95022024000501216

Exercise and anabolic steroids are expected to promote improvements in cardiovascular structure and reduction of visceral fat and, thus, help promote health in hyperglycemic patients. The aim of this study was to verify the influence of aerobic exercise associated with the use of steroids on cardiac structure and visceral fat in hyperglycemic Wistar rats. Methods: Thirty-two young male Wistar rats were divided into four groups: control group (n=8), control with treatment (n=8), diabetic (n=8) and diabetic with treatment (n=8). All animals were subjected to intense aerobic exercise and the animals undergoing treatment received intramuscular testosterone. Body weight, visceral fat and cardiac measurements (weight, length and width) were evaluated. The groups treated with testosterone showed a smaller than expected increase in body weight for food intake. Visceral, perirenal, retroperitoneal and epididymal fats were lower in the treated groups. Heart weight was relatively greater in the treated groups and greater width and length in the untreated groups. The proposed association of testosterone administration with aerobic exercise can provide significant benefits for the metabolism of hyperglycemic individuals.