Synthesis and antibacterial activity of cefotaxime metal complexes

Cefotaxime (Hcefotax) interacts with transition metal ions to give [M(cefotax)Cl] complexes (M = Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Cd(II)) which were characterized by physicochemical and spectroscopic methods and a tetrahedral geometry is suggested for their structure. The IR and the ¹H-NM...

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Bibliographic Details
Published in:Journal of the Chilean Chemical Society 2005-06, Vol.50 (2), p.447-450
Main Authors: Anacona, J.R., Silva, Gladys Da
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
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Summary:Cefotaxime (Hcefotax) interacts with transition metal ions to give [M(cefotax)Cl] complexes (M = Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Cd(II)) which were characterized by physicochemical and spectroscopic methods and a tetrahedral geometry is suggested for their structure. The IR and the ¹H-NMR spectra of the complexes suggest that the cefotaxime behaves as monoanionic tridentate ligand . The complexes have been screened for antibacterial activity against several bacteria, and the results are compared with the activity of cefotaxime
ISSN:0717-9707
0717-9707
DOI:10.4067/S0717-97072005000200001