A CONVENIENT SYNTHESIS AND CYTOTOXIC ACTIVITY OF 3-ARYL-5-PENTYL-1,2,4-OXADIAZOLES FROM CARBOXYLIC ACID ESTERS AND ARYLAMIDOXIMES UNDER SOLVENT-FREE CONDITIONS

The synthesis of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes in the presence of potassium carbonate is described. The reaction was carried out in a microwave oven without any solvent in much shorter time and in good yields. The structures of the synthesized compo...

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Published in:Journal of the Chilean Chemical Society 2014-03, Vol.59 (1), p.2359-2362
Main Authors: PIMENTEL BARROS, CARLOS JONNATAN, CARDOSO DE SOUZA, ZILYANE, DE FREITAS, JUCLEITON JOSÉRUFINO, NORBERTO DA SILVA, PAULO BRUNO, GADELHA MILITÃO, GARDENIA CARMEN, GONÇALVES DA SILVA, TERESINHA, RUFINO FREITAS, JULIANO CARLO, DE FREITAS FILHO, JOÃO RUFINO
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
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Summary:The synthesis of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes in the presence of potassium carbonate is described. The reaction was carried out in a microwave oven without any solvent in much shorter time and in good yields. The structures of the synthesized compounds were elucidated using IR, ¹H and 13C NMR spectroscopy and elemental analysis and their antiproliferative activities was evaluated against three different human cell lines.
ISSN:0717-9707
0717-9707
DOI:10.4067/S0717-97072014000100024