BlaGES carrying Pseudomonas aeruginosa isolates from a public hospital in Rio de Janeiro, Brazil

Previous analysis of Pseudomonas aeruginosa class-1 integrons from Rio de Janeiro, Brazil, revealed the blaGES gene in one isolate. We screened isolates of two widespread PFGE genotypes, A and B, at a public hospital in Rio, for the presence of blaGES. The gene was detected in all seven P. aeruginos...

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Bibliographic Details
Published in:The Brazilian journal of infectious diseases 2006-08, Vol.10 (4), p.251-253
Main Authors: Pellegrino, Flávia L P C, Netto-dos Santos, Kátia R, Riley, Lee W, Moreira, Beatriz M
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
beta-Lactamases - biosynthesis
blaGES, antibiotics
Brazil
Drug Resistance, Multiple, Bacterial - genetics
Drug Synergism
Genotype
Hospitals, Public
Humans
INFECTIOUS DISEASES
Microbial Sensitivity Tests
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - genetics
Pseudomonas aeruginosa - isolation & purification
Pseudomonas Infections - microbiology
public hospital
Rio de Janeiro
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Summary:Previous analysis of Pseudomonas aeruginosa class-1 integrons from Rio de Janeiro, Brazil, revealed the blaGES gene in one isolate. We screened isolates of two widespread PFGE genotypes, A and B, at a public hospital in Rio, for the presence of blaGES. The gene was detected in all seven P. aeruginosa isolates belonging to genotype B. Three of the seven genotype-B isolates were resistant to amikacin, aztreonam, ceftazidime, cefepime, ciprofloxacin, gentamicin, imipenem, meropenem, piperacillin-tazobactam and ticarcillin-clavulanic acid. The other four isolates were resistant to all these agents, except gentamicin, imipenem, meropenem and piperacillin-tazobactam. A synergistic effect between ceftazidime and imipenem or clavulanic acid suggested the production of GES-type ESBL.
ISSN:1413-8670
1678-4391
DOI:10.1590/S1413-86702006000400007