Neurological profile and neurodevelopment of 88 children infected with HIV and 84 seroreverter children followed from 1995 to 2002

This study evaluated the degree of neurological compromise in HIV-infected children accompanied by the outpatient clinic of infectious diseases and pediatric neurology of the Clinical Hospital of the Federal University of Paraná (UFPR) starting in 1995. Long-term progressive prospective and cross se...

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Published in:The Brazilian journal of infectious diseases 2006-10, Vol.10 (5), p.322-326
Main Authors: Tahan, Tony Tannous, Bruck, Isac, Burger, Marion, Cruz, Cristina Rodrigues
Format: Article
Language:English
Subjects:
AIDS Dementia Complex - diagnosis
CAT/CLAMS
Child
Child Development
Child, Preschool
Cross-Sectional Studies
DENVER I
DENVER II
Developmental Disabilities - diagnosis
Female
HIV Seronegativity
HIV-infected children
HIV-seroverter children
Humans
Infant
Infant, Newborn
INFECTIOUS DISEASES
Male
neurodevelopment
Neurologic Examination
Neuropsychological Tests
Prospective Studies
Tomography, X-Ray Computed
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container_title The Brazilian journal of infectious diseases
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creator Tahan, Tony Tannous
Bruck, Isac
Burger, Marion
Cruz, Cristina Rodrigues
description This study evaluated the degree of neurological compromise in HIV-infected children accompanied by the outpatient clinic of infectious diseases and pediatric neurology of the Clinical Hospital of the Federal University of Paraná (UFPR) starting in 1995. Long-term progressive prospective and cross sectional study of 88 children infected by HIV and 84 seroreverter children, using data from general neurological examinations, neuroimaging procedures (brain CT scan) and neurodevelopmental tests (CAT/CLAMS and DENVER I and II). Neurological and neurodevelopmental alterations were found in 82% of the HIV-infected patients and in 36% of the HIV-seroreverter group (P
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Long-term progressive prospective and cross sectional study of 88 children infected by HIV and 84 seroreverter children, using data from general neurological examinations, neuroimaging procedures (brain CT scan) and neurodevelopmental tests (CAT/CLAMS and DENVER I and II). Neurological and neurodevelopmental alterations were found in 82% of the HIV-infected patients and in 36% of the HIV-seroreverter group (P&lt;0.01). In the CAT/CLAMS test, the development quotient (DQ) of the HIV-infected group was significantly lower than that of the HIV-seroreverter group. CAT/CLAMS scores lower than 70 (mental deficiency) were found in 31% of the HIV-infected patients during the first year of life and in only 1% of the patients of the HIV-seroreverter group, demonstrating the validity of this screening test for precocious detection of alterations in the neurodevelopment of infected patients. The same occurred with the Denver I and II tests, as the HIV-infected group failed more frequently than the HIV-seroreverter group. Nine HIV-infected children presented altered brain CT scans; calcification of basal ganglia was the main finding (five cases). 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Long-term progressive prospective and cross sectional study of 88 children infected by HIV and 84 seroreverter children, using data from general neurological examinations, neuroimaging procedures (brain CT scan) and neurodevelopmental tests (CAT/CLAMS and DENVER I and II). Neurological and neurodevelopmental alterations were found in 82% of the HIV-infected patients and in 36% of the HIV-seroreverter group (P&lt;0.01). In the CAT/CLAMS test, the development quotient (DQ) of the HIV-infected group was significantly lower than that of the HIV-seroreverter group. CAT/CLAMS scores lower than 70 (mental deficiency) were found in 31% of the HIV-infected patients during the first year of life and in only 1% of the patients of the HIV-seroreverter group, demonstrating the validity of this screening test for precocious detection of alterations in the neurodevelopment of infected patients. The same occurred with the Denver I and II tests, as the HIV-infected group failed more frequently than the HIV-seroreverter group. Nine HIV-infected children presented altered brain CT scans; calcification of basal ganglia was the main finding (five cases). 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The same occurred with the Denver I and II tests, as the HIV-infected group failed more frequently than the HIV-seroreverter group. Nine HIV-infected children presented altered brain CT scans; calcification of basal ganglia was the main finding (five cases). Encephalopathy due to HIV causes early arrest of neurodevelopment, which can be detected with screening tests during the first year of life.</abstract><cop>Brazil</cop><pub>Brazilian Society of Infectious Diseases</pub><pmid>17293919</pmid><doi>10.1590/S1413-86702006000500004</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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ispartof The Brazilian journal of infectious diseases, 2006-10, Vol.10 (5), p.322-326
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1678-4391
1413-8670
language eng
recordid cdi_scielo_journals_S1413_86702006000500004
source SciELO Brazil
subjects AIDS Dementia Complex - diagnosis
CAT/CLAMS
Child
Child Development
Child, Preschool
Cross-Sectional Studies
DENVER I
DENVER II
Developmental Disabilities - diagnosis
Female
HIV Seronegativity
HIV-infected children
HIV-seroverter children
Humans
Infant
Infant, Newborn
INFECTIOUS DISEASES
Male
neurodevelopment
Neurologic Examination
Neuropsychological Tests
Prospective Studies
Tomography, X-Ray Computed
title Neurological profile and neurodevelopment of 88 children infected with HIV and 84 seroreverter children followed from 1995 to 2002
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