Platelet aggregation and lipoprotein levels in a patient with familial hypercholescholesterolemia after selective LDL-apheresis

Platelet aggregation was studied in a patient with familial hypercholesterolemia immediately after aphereis selective for low-density lipoprotein (LDL), a lipid-lowering procedure.This treatment reduced plasmatic levels of total and LDL-cholesterol, apo B, and triglyceride. Increased platelet aggreg...

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Bibliographic Details
Published in:São Paulo medical journal 1997-06, Vol.115 (3), p.1448-1451
Main Authors: Pares, Madalena Nunes da Silva, D'Amico, Elbio Antonio, Kutner, José Mauro, Chamone, Dalton de Alencar Fischer, Bydlowski, Sergio Paulo
Format: Article
Language:English
Subjects:
Familial hypercholesterolemia
LDL-apheresis
MEDICINE, GENERAL & INTERNAL
Platelet aggregation
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Summary:Platelet aggregation was studied in a patient with familial hypercholesterolemia immediately after aphereis selective for low-density lipoprotein (LDL), a lipid-lowering procedure.This treatment reduced plasmatic levels of total and LDL-cholesterol, apo B, and triglyceride. Increased platelet aggregation was reduced immediately after the apheresis in whole blood as well as in platelet-rich plasma. However, aggregation in washed platelets remained unchanged after LDL-apheresis. In conclusion, in this patient reduction of LDL-cholesterol improved platelet function in the very short term. A agregação plaquetária foi estudada em um paciente com hipercolesterolemia familiar imediatamente após aférese seletiva para lipoproteína de baixa densidade (LDL), para diminuição dos lípides plasmáticos. O tratamento reduziu os níveis plasmáticos de colesterol total, LDL-colesterol, apo B e triglicérides. A agregação plaquetária aumentada foi reduzida, imediatamente após aférese, em sangue total e em plasma rico em plaquetas, mas permanaceu sem modificações em plaquetas lavadas. Em conclusão, neste paciente, a redução dos níveis de LDL-colesterol melhorou a função plaquetária, pelo menos a muito curto prazo.
ISSN:1516-3180
1806-9460
1516-3180
DOI:10.1590/S1516-31801997000300009