Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models

The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder...

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Published in:Revista brasileira de psiquiatria 2022-02, Vol.44 (1), p.74-80
Main Authors: Reckziegel, Ramiro, Czepielewski, Letícia S., Hasse-Sousa, Mathias, Martins, Dayane S., de Britto, Maria J., Lapa, Clara de O., Schwartzhaupt, Alexandre W., Gama, Clarissa S.
Format: Article
Language:Portuguese
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PSYCHIATRY
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Summary:The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient.
ISSN:1809-452X
DOI:10.1590/1516-4446-2020-1670