Evaluation of the changes on hemostatic parameters induced by valdecoxib in male Wistar rats

The effects of the cyclooxygenase (COX)-2 selective inhibitor, valdecoxib, on blood coagulation parameters were evaluated, along with aspirin in male Wistar rats. Groups of animals were administered a daily oral dose of 10 mg/kg rat of valdecoxib, 100 mg/kg rat of aspirin and the vehicle alone durin...

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Published in:Revista brasileira de hematologia e hemoterapia 2006-03, Vol.28 (1), p.28-32
Main Authors: Fronza, Marcio, Wrasse, Micheli, Brum Junior, Liberato, Sangoi, Maximiliano S., Dalmora, Sérgio L.
Format: Article
Language:English
Subjects:
HEMATOLOGY
MEDICINE, RESEARCH & EXPERIMENTAL
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Summary:The effects of the cyclooxygenase (COX)-2 selective inhibitor, valdecoxib, on blood coagulation parameters were evaluated, along with aspirin in male Wistar rats. Groups of animals were administered a daily oral dose of 10 mg/kg rat of valdecoxib, 100 mg/kg rat of aspirin and the vehicle alone during 4 weeks. Blood samples were collected at the end of 1, 2, 3 and 4 weeks of administration period and the plasma concentrations of valdecoxib were determined by RP-HPLC giving mean values of 101.1, 113.5, 164.0 and 184.6 ng/mL, respectively. The same plasma samples were used for the analysis of hematological parameters and the results compared to the controls. Valdecoxib induced significant activated partial thromboplastin time reduction (18%) after 2 weeks and prothrombin time reduction (12.2%) after 3 weeks (P
ISSN:1516-8484
1806-0870
1516-8484
DOI:10.1590/S1516-84842006000100008