Assessment of acute and subchronic oral toxicity of ethanolic extract of Pothomorphe umbellata L. Miq (Pariparoba)

There is a high degree of concern regarding the secure use of plant extracts and, for this very reason, preclinical and clinic toxicological evaluation of these extracts are needed. With the aim to assure the quality and the safety of the extract and due to the scarcity of literature information abo...

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Bibliographic Details
Published in:Revista brasileira de ciências farmacêuticas 2005-03, Vol.41 (1), p.53-61
Main Authors: Barros, Sonia, Ropke, Cristina Dislich, Sawada, Tânia Cristina Higashi, Silva, Vanessa Vitoriano da, Pereira, Sônia Maria Miranda, Barros, Silvia Berlanga de Moraes
Format: Article
Language:English
Subjects:
PHARMACOLOGY & PHARMACY
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Summary:There is a high degree of concern regarding the secure use of plant extracts and, for this very reason, preclinical and clinic toxicological evaluation of these extracts are needed. With the aim to assure the quality and the safety of the extract and due to the scarcity of literature information about Pariparoba extract toxicity, our purpose was to investigate the acute and subchronic toxicity of the standardized ethanolic dried root extract of Pothomorphe umbellata L. Miq. This extract was administered orally to adult swiss mice and wistar rats and the mutagenic potencial of the extract was also evaluated. The extract showed to be non toxic.
ISSN:1516-9332
1516-9332
DOI:10.1590/S1516-93322005000100005