Prevalence of genotypes in Helicobacter pylori isolates from patients in eastern Turkey and the association of these genotypes with clinical outcome

There is not much information available regarding the prevalence of the genotypes of Helicobacter pylori isolates in Turkey, particularly in eastern Turkey. The aims of this study were to detect the prevalence of different genotypes of H. pylori in Turkish patients with gastrointestinal complaints a...

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Bibliographic Details
Published in:Brazilian journal of microbiology 2012-10, Vol.43 (4), p.1332-1339
Main Authors: Ozbey, Gokben, Aygun, Cem
Format: Article
Language:English
Subjects:
Bacteria
Bacterial infections
Clinical outcomes
Epidemiology
Genotype & phenotype
MICROBIOLOGY
Minority & ethnic groups
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Summary:There is not much information available regarding the prevalence of the genotypes of Helicobacter pylori isolates in Turkey, particularly in eastern Turkey. The aims of this study were to detect the prevalence of different genotypes of H. pylori in Turkish patients with gastrointestinal complaints and to determine the relationship of these genotypes with clinical outcome and sex. One hundred forty H. pylori isolates were examined for the presence of its genotypes by the PCR. We found that the prevalence of vacA s1, vacA s2, cagA, cagE, iceA1, iceA2 and babA2 genes were 88.6%, 11.4%, 71.4%, 35.7%, 41.4%, 58.6%, and 62.1%, respectively. The most predominant vacA subtype was s1a (81.4%). The most vacA allelic combination detected were vacA s1m1 (65.2%)and s1m2 (53.9%) in patients with peptic ulcer and gastritis, respectively. The only vacA s1 isolate was significantly associated with gastritis and peptic ulcer (p
ISSN:1517-8382
1678-4405
1678-4405
DOI:10.1590/S1517-83822012000400014