Analysis of risk factors and clinical manifestations associated with Clostridium difficile disease in Serbian hospitalized patients

• Published in: Brazilian journal of microbiology 2016-10, Vol.47 (4), p.902-910
• Main Author: Predrag, Stojanović
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Case-Control Studies; Clostridioides difficile - isolation & purification; Clostridioides difficile - metabolism; Clostridium difficile; Clostridium Infections - diagnosis; Clostridium Infections - drug therapy; Clostridium Infections - epidemiology; Clostridium Infections - microbiology; Cross Infection; Hospital-acquired diarrhoea; Hospitalization; Humans; Medical Microbiology; MICROBIOLOGY; Odds Ratio; Risk Factors; Serbia; Serbia - epidemiology
• ISSN: 1517-8382; 1678-4405; 1678-4405
• DOI: 10.1016/j.bjm.2016.07.011

Clostridium difficile is the leading cause of infectious diarrhoea in hospitalized patients. The aim of this study was to determine the risk factors important for the development of hospital-acquired Clostridium difficile-associated disease and clinical manifestations of Clostridium difficile-associated disease. The clinical trial group included 37 hospitalized patients who were selected according to the inclusion criteria. A control group of 74 hospitalized patients was individually matched with cases based on hospital, age (within 4 years), sex and month of admission. Clostridium difficile-associated disease most commonly manifested as diarrhoea (56.76%) and colitis (32%), while in 8.11% of patients, it was diagnosed as pseudomembranous colitis, and in one patient, it was diagnosed as fulminant colitis. Statistically significant associations (p