ASSOCIATION OF ACTN3 R577X AND ACE I/D POLYMORPHISMS IN BRAZILIANS WRESTLERS

• Published in: Revista brasileira de medicina do esporte 2017-12, Vol.23 (6), p.469-472
• Main Authors: Ribas, Marcelo Romanovitch, Oliveira Netto, Zair Candido, Salgueirosa, Fabiano, Fernandes, Priscila, Matos, Oslei de, Bassan, Julio Cesar
• Format: Article
• Language: English
• Subjects: PHYSIOLOGY; SPORT SCIENCES
• ISSN: 1517-8692; 1806-9940; 1806-9940
• DOI: 10.1590/1517-869220172306171864

ABSTRACT Introduction: By associating genetics and sport, it is possible to identify subjects with greater capacity to adapt to training, and lower chances of injury. Objective: The investigation evaluated the genotypic and allelic distribution of ACTN3 R577X and ACE I/D polymorphisms in Brazilian high-performance athletes in wrestling and percussion combat sports. Methods: The study included 37 male athletes ranked from first to third place in world scenarios, divided into two groups: wrestling (23 wrestlers, being 11 of Judo, 4 of Greco-Roman style, 8 of Brazilian Jiu Jitsu, with mean age of 27.3 ± 6.9 years) and percussion combat sports (14 athletes with a mean age of 25.7±4.4 years, being 6 of Karate, 3 of Muay Thai, 4 of Taekwondo, 1 Boxing). Genotyping of ACTN3 and ACE I/D polymorphisms was performed by polymerase chain reaction (PCR) from the genomic DNA. Genotypic and allelic distributions were compared with control populations and athletes by Chi-square test and Fisher’s exact test; all analyzes considered p ≤ 0.05. Results: The genotypic distributions and allelic frequencies of ACTN3 RR=46%, RX=38% and XX=16%; R=65% and X=35%, and ACE I/D DD=47.7%, ID=34.3% and II=20%; D=62.9% and I=37.1% did not differ from the control population; however, when compared with wrestling athletes a significant difference was observed. Conclusion: These results suggest an association of ACTN3 R577X and ACE I/D genes with Brazilian high-performance wrestling athletes. RESUMEN Introducción: Al asociar genética y deporte, existe la posibilidad de identificar sujetos con mayor capacidad de adaptación a los entrenamientos con menores posibilidades de lesión. Objetivo: La investigación evaluó la distribución genotípica y alélica de los polimorfismos ACTN3 R577X y ACE I/D en luchadores brasileños de alto rendimiento de técnicas de agarre y golpeo. Métodos: Participaron en el estudio 37 atletas del sexo masculino, colocados de primer a tercer lugar en escenarios mundiales, divididos en dos grupos: agarre (23 luchadores, siendo 11 de judo, 4 de lucha grecorromana y 8 de jiu-jitsu; el promedio de edad fue de 27,3 ± 6,9 años) y golpeo (14 atletas con promedio de edad de 25,7 ± 4,4 años, siendo 6 de karate, 3 de muay-thai, 4 de taekwondo y 1 de boxeo). El genotipado de los polimorfismos de ACTN3 y ACE I/D se llevó a cabo por reacción en cadena de la polimerasa (PCR) a partir de ADN genómico. Las distribuciones genotípicas y alélicas fueron comparadas con poblaciones control y a