ACUTE EFFECT OF DIFFERENT TYPES OF EXERCISE ON NATRIURETIC PEPTIDES OF WISTAR RATS

• Published in: Revista brasileira de medicina do esporte 2019-08, Vol.25 (4), p.310-315
• Main Authors: Pianca, Eduardo Vitor, Krause Neto, Walter, Silva, Alexandre Sabbag da, Gama, Eliane Florencio, Souza, Romeu Rodrigues de
• Format: Article
• Language: English
• Subjects: PHYSIOLOGY; SPORT SCIENCES
• ISSN: 1517-8692; 1806-9940; 1806-9940
• DOI: 10.1590/1517-869220192504214335

ABSTRACT Introduction: The study of the effects of different types of physical exercise on cardiovascular physiology is increasing in the literature. The many mechanisms of hemodynamic control include the atrial release of natriuretic peptides. Although extensive evidence demonstrates their acute effects and the increase in their plasma concentration, it is not known whether both atria respond in a similar way to both types of natriuretic peptide in response to different types of exercise. Objective: To compare the acute responses of different exercise types in the atrial (ANP) and brain (BNP) natriuretic peptides of both atrial cardiomyocytes of Wistar rats. Methods: Animals were divided into control (CG), aerobic (AG), resistance (RG) and combined (ARG). The RG performed six climbs, with a load equivalent to 60% of body weight. The AG ran on a treadmill at a speed of 12m/min for 60 minutes. The ARG exercise consisted of three consecutive ladder climbs, followed by 30 minutes of running. Results: First, the right atrium released more ANP and BNP during all types of exercise; second, the resistance exercise released the most ANP and BNP in both atria; third, in the right atrium, aerobic and combined workouts released more small and medium ANP granules while resistance exercise released larger BNP granules; and fourth, in the left atrium, aerobic exercise released more ANP granules while resistance and combined exercise released larger ANP and BNP granules. Conclusion: All types of exercise induce partial release of natriuretic peptide granules, with greater response to resistance exercise. Furthermore, a particular and different response could be seen in both types of atria in the release of ANP and BNP. Level of evidence II; Therapeutic studies - Investigation of treatment results. RESUMO Introdução: O estudo dos efeitos de diferentes tipos de exercício físico na fisiologia cardiovascular está aumentando na literatura. Os muitos mecanismos de controle hemodinâmico incluem a liberação atrial de peptídeos natriuréticos. Embora amplas evidências demonstrem seus efeitos agudos e o aumento na sua concentração plasmática, não se sabe se ambos os átrios respondem de maneira semelhante aos dois tipos de peptídeos natriuréticos em resposta a diferentes tipos de exercício. Objetivo: Comparar as respostas agudas de diferentes tipos de exercícios nos peptídeos natriuréticos atrial (ANP) e cerebral (BNP) de ambos os cardiomiócitos atriais dos ratos Wistar. Métodos: Os