Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus

Abstract Objectives: to determine the frequency of serum markers for hereditary and acquired thrombophilia and their association with pregnancy in women with Systemic Lupus Erythematosus (SLE). Methods: a case-control study was conducted among 25 pregnant women with SLE (study group) and 32 pregnant...

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Bibliographic Details
Published in:Revista Brasileira de Saúde Materno Infantil 2017-12, Vol.17 (4), p.833-842
Main Authors: Oliveira, Vanessa Marcon de, Figueiró-Filho, Ernesto Antonio, Ferreira, Cristiane Munaretto, Pereira, Erica Freire de Vasconcelos
Format: Article
Language:English
Subjects:
Antiphospholipid syndrome
hematologic
PEDIATRICS
Pregnancy complications
Systemic lupus erythematosus
Thrombophilia
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Summary:Abstract Objectives: to determine the frequency of serum markers for hereditary and acquired thrombophilia and their association with pregnancy in women with Systemic Lupus Erythematosus (SLE). Methods: a case-control study was conducted among 25 pregnant women with SLE (study group) and 32 pregnant women without known disease and with at least one previous pregnancy (control group). The presence of antiphospholipid antibodies and hereditary thrombophilia were examined in both groups. We used the y2 Test with Yates correction or Fisher's Exact Test to verify the associations and calculate the relative risk. Results: thrombophilia was present in 72.0% of pregnant women with SLE and in 6.0% of patients in the control group. A significant association was found between the presence of SLE and serum markers for hereditary thrombophilia / antiphospholipid antibodies (p
ISSN:1806-9304
1806-9304
DOI:10.1590/1806-93042017000400012