Comparative study between immunoturbidimetric and latex agglutination methods for the detection of rheumatoid factor

INTRODUCTION: The rheumatoid factor (RF) is the most common antibody found in patients with rheumatoid arthritis. It is an inflammatory chronic disease characterized by articular involvement, inflammation of synovial fluid, tissue infiltration by leucocytes and joint destruction, which ultimately de...

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Published in:Jornal brasileiro de patologia e medicina laboratorial 2013-02, Vol.49 (1), p.12-16
Main Authors: Rocha, Katya Cristina, Brinque, Luiz Alberto da Fonseca, Oliveira, Claudia G. B., Sant'Anna, Aleksandra Vanessa Lambiasi, Fonseca, Alexandre Luiz Affonso, Azzalis, Ligia Ajaime, Pereira, Edimar Cristiano, Junqueira, Virginia Berlanga Campos, Beltrame, Registila Libania, Fonseca, Fernando Luiz Affonso
Format: Article
Language:English
Subjects:
MEDICAL LABORATORY TECHNOLOGY
MEDICINE, RESEARCH & EXPERIMENTAL
PATHOLOGY
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Summary:INTRODUCTION: The rheumatoid factor (RF) is the most common antibody found in patients with rheumatoid arthritis. It is an inflammatory chronic disease characterized by articular involvement, inflammation of synovial fluid, tissue infiltration by leucocytes and joint destruction, which ultimately determine articular deformities. The rheumatoid factor is found in 70%-80% of the adult population and in 10% of the young population. OBJECTIVE: The aim of this research was to compare immunoturbidimetric and latex agglutination methods for the detection of RF in serum. RESULTS: The immunoturbidimetric method displayed sensitivity (95.2%), specificity (89.4%) and high positive correlation (R² = 0,8077) with the latex agglutination method in positive serum samples. CONCLUSION: The study allowed to demonstrate that both immunoturbidimetric and latex agglutination methods equally discriminate between negative and positive serum samples for RF.
ISSN:1676-2444
1678-4774
DOI:10.1590/S1676-24442013000100002