Histological analysis of autologous fascia graft implantation into the rabbit voice muscle

The ideal approach for the treatment of glottal insufficiency remains a challenge for laryngologists. This experimental study assessed the histological changes and fibrosis caused by autologous fascia lata grafts into the rabbit voice muscle. A clinical and experimental study. A 0.2 × 0.2 cm fragmen...

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Bibliographic Details
Published in:Brazilian journal of otorhinolaryngology 2011-03, Vol.77 (2), p.185-190
Main Authors: de Rezende Pinna, Bruno, Stavale, João Norberto, de Lima Pontes, Paulo Augusto, de Oliveira Camponês do Brasil, Osíris
Format: Article
Language:English
Subjects:
Animals
fascia
Fascia Lata - transplantation
glottis
Inflammation
laryngeal diseases
Laryngeal Muscles - pathology
Laryngeal Muscles - surgery
Male
Original
OTORHINOLARYNGOLOGY
Rabbits
Transplantation, Autologous
vocal cords
Vocal Cords - pathology
Vocal Cords - surgery
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Summary:The ideal approach for the treatment of glottal insufficiency remains a challenge for laryngologists. This experimental study assessed the histological changes and fibrosis caused by autologous fascia lata grafts into the rabbit voice muscle. A clinical and experimental study. A 0.2 × 0.2 cm fragment of autologous fascia lata was grafted into the right voice muscle of 14 adult rabbits. Animals were euthanized 30 or 60 days post-procedure and histology of the excised vocal folds was carried out. No extensive edema, necrosis or foreign body-type reaction was observed at any time. No significant inflammatory reaction or fibrosis was seen at 30 or 60 days. The presence of fascia lata in the rabbit voice muscle had no significant influence on inflammation, and does not increase fibrosis. Rabbit voice muscle shows good tolerance to fascia lata grafting.
ISSN:1808-8694
1808-8686
1808-8686
DOI:10.1590/S1808-86942011000200008