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Current outlook of ethics in research with human subjects

In the last decades, medical care has been increasingly permeated by the concept of evidencebased-medicine, in which clinical research plays a crucial role in establishing diagnostic and treatment. Following the improvements in clinical research, we have a growing concern and understanding that some...

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Published in:	Brazilian journal of otorhinolaryngology 2011-03, Vol.77 (2), p.263-266
Main Authors:	Takahashi, Marystella Tomoe, Ramos, Henrique Faria, Pinheiro-Neto, Carlos Diógenes, Miziara, Ivan Dieb, de Oliveira, Reynaldo Ayer
Format:	Article
Language:	English
Subjects:	bioethics Brazil codes of ethics ethics ethics committees Ethics, Research Human Experimentation - ethics Human Experimentation - legislation & jurisprudence Humans OTORHINOLARYNGOLOGY principle-bases ethics Review
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container_title	Brazilian journal of otorhinolaryngology
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creator	Takahashi, Marystella Tomoe Ramos, Henrique Faria Pinheiro-Neto, Carlos Diógenes Miziara, Ivan Dieb de Oliveira, Reynaldo Ayer
description	In the last decades, medical care has been increasingly permeated by the concept of evidencebased-medicine, in which clinical research plays a crucial role in establishing diagnostic and treatment. Following the improvements in clinical research, we have a growing concern and understanding that some ethical issues must be respected when the subjects are human beings. Research with human subjects relies on the principles of autonomy, beneficence, no maleficence and justice. Ordinance 196/96 from the National Health Board adds to the Brazilian legislation such renowned bioethical principles. Discuss the main ethical aspects involved in research with human subjects. Critical analysis of Ordinance 196/96 and related literature. Ordinance 196/96 rules research with human subjects; nevertheless, it requires more in-depth discussions regarding the informed consent, use of placebo, research with vulnerable populations and research in developing countries.
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subjects	bioethics Brazil codes of ethics ethics ethics committees Ethics, Research Human Experimentation - ethics Human Experimentation - legislation & jurisprudence Humans OTORHINOLARYNGOLOGY principle-bases ethics Review
title	Current outlook of ethics in research with human subjects
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