The effect of dexamethasone on post-tonsillectomy nausea, vomiting and bleeding

It has been stated, that the administration of Dexamethasone has an impact on the morbidity following tonsillectomy. To re-calculate the blood values for Dexamethasone when given as fixed doses and to evaluate the effect of Dexamethasone on post-operative nausea, vomiting and bleeding rates followin...

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Bibliographic Details
Published in:Brazilian journal of otorhinolaryngology 2011-06, Vol.77 (3), p.373-379
Main Authors: Windfuhr, Jochen P., Chen, Yue-Shih, Propst, Evan J., Güldner, Christian
Format: Article
Language:English
Subjects:
Adolescent
Antiemetics - analysis
Antiemetics - blood
Antiemetics - therapeutic use
Child
Child, Preschool
dexamethasone
Dexamethasone - blood
Dexamethasone - therapeutic use
Female
hemorrhage
Humans
Male
Original
OTORHINOLARYNGOLOGY
postoperative complications
Postoperative Hemorrhage - etiology
Postoperative Nausea and Vomiting - prevention & control
Premedication
Preoperative Care
tonsillectomy
Tonsillectomy - adverse effects
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Summary:It has been stated, that the administration of Dexamethasone has an impact on the morbidity following tonsillectomy. To re-calculate the blood values for Dexamethasone when given as fixed doses and to evaluate the effect of Dexamethasone on post-operative nausea, vomiting and bleeding rates following tonsillectomy. The charts of 272 children (2–15 years) who had undergone tonsillectomy were analyzed. The rates of post-operative nausea, vomiting and bleeding in relation to Dexamethasone were calculated-in general and different doses (0 mg/kg, 0.15 mg/kg). Retrospective cohort study. Dexamethasone was administered in 121 children (43.7%) according to the preference of the anesthesist (mean dose: 0.2 +/- 0.12 mg/kg; range: 0.04 - 0.62 mg/kg). There was no significant difference in nausea and vomiting (p=0.953) or bleeding (p=0.827) across groups receiving or not receiving Dexamethasone. Stratification into three different groups of Dexamethasone concentration also did not identify a dose-related risk of postoperative nausea or vomiting (p=0.98) or bleeding (p=0.71). At least under common non-controlled conditions in the clinic, Dexamethasone does not appear to have an effect on nausea or vomiting or bleeding following tonsillectomy.
ISSN:1808-8694
1808-8686
1808-8686
DOI:10.1590/S1808-86942011000300017