γ-Lactones Upon Double Nucleophilic Additions of Bis(TMS)Ketene Acetals to Π-systems and Access to New-towards Cancer Cells Cytotoxic-Endoperoxide Lactones

Arenechromium and cycloheptatrienechromium complexes react with (TMS)ketene acetals to give upon a double nucleophilic addition either diene-lactones or cyclohexenone-lactones. In the first case, the scope of the reaction and the stability of the dienes were examined: they could be easily transforme...

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Bibliographic Details
Published in:Journal of the Mexican Chemical Society 2008-06, Vol.52 (2), p.145-174
Main Authors: Rudler, Henri, Aldeco-Pérez, Eugenia, Parlier, Andrée, Álvarez, Cecilio, Chaquin, Patrick, Herson, Patrick, Toscano, Alfredo, Ramírez-Apan, María-Teresa
Format: Article
Language:eng ; por
Subjects:
Chemistry, Multidisciplinary
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Summary:Arenechromium and cycloheptatrienechromium complexes react with (TMS)ketene acetals to give upon a double nucleophilic addition either diene-lactones or cyclohexenone-lactones. In the first case, the scope of the reaction and the stability of the dienes were examined: they could be easily transformed either in arylpropionic acids or in conjugated ketones and more interestingly, they reacted with oxygen to give new highly active cytotoxic endoperoxide lactones. Unfortunately, in the second case, no further functionalization could be achieved up to now.
ISSN:1870-249X