Preparation and Some Reactions with 3-(Quinolin-3-yl)-3-Oxopropanoic Acid

Preparation of quinolinyl-3-oxopropanoic acid 2 was accomplished by hydrolysis of pyranoquinolinedione 1 in aqueous alkaline medium. The chemical behavior of this β-keto acid 2 towards nitrosation, coupling with a diazonium salt, esterification, condensation with 2,2-dimethoxyethanamine, hydrazinoly...

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Bibliographic Details
Published in:Journal of the Mexican Chemical Society 2011-10, Vol.55 (4), p.224-232
Main Authors: Abass, Mohamed, Mohamed, Elhossain A., Ismail, Mostafa M., Mayas, Aisha S.
Format: Article
Language:eng ; por
Subjects:
Chemistry, Multidisciplinary
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Summary:Preparation of quinolinyl-3-oxopropanoic acid 2 was accomplished by hydrolysis of pyranoquinolinedione 1 in aqueous alkaline medium. The chemical behavior of this β-keto acid 2 towards nitrosation, coupling with a diazonium salt, esterification, condensation with 2,2-dimethoxyethanamine, hydrazinolysis, Knoevenagel condensation with isatine, salisyaldehyde, 3-formylquinolones, and 3-formylchromone, was investigated. Also many of the products of these reactions were found obtainable using either pyranoquinolinedione 1 or β-keto acid 2, under the same conditions.
ISSN:1870-249X