Research Trends on Preventive and Therapeutic Use of TIF4 for Dental Caries and Erosion

• Published in: Pesquisa brasileira em odontopediatria e clínica integrada 2022-01, Vol.22
• Main Authors: Chevitarese, Ana Beatriz, Leite, Karla Lorene de França, Marañón-Vásquez, Guido Artemio, Masterson, Danielle, Vicente-Gomila, José M., Gonçalves, Andréa Fonseca, Pitton, Matheus, Maia, Lucianne Cople
• Format: Article
• Language: English
• Subjects: DENTISTRY, ORAL SURGERY & MEDICINE
• ISSN: 1519-0501; 1983-4632; 1983-4632
• DOI: 10.1590/pboci.2022.079

Abstract Objective: To evaluate TIF4 preventive and therapeutic use in caries and erosive lesions. Material and Methods: Searches were performed in six databases. Studies evaluating TiF4 use in vitro, in situ, and in vivo in caries and erosive lesions were included and imported into VantagePoint™ (VP). Data about publication year, authors, country, journal, study design, outcomes, TIF4 vehicles, application and intervention time, cariogenic challenge, erosive cycles, effects (positive/ negative /null) and approach (preventive/therapeutic) were analyzed through VP and Excel. Results: 93 published studies were included and an increase in publications was observed between 2010 and 2021. Forty-three authors published three or more articles, of which 67.4% were developed in Brazil and published in Caries Research (22.6%). 69.9% were in vitro studies with erosion assays (59.1%) and with preventive approaches (67.4%). The principal vehicle was a solution (69.9%) with a 1-min single application (58.0%) and with an intervention time of 5-7 days (22.6%). The principal cariogenic challenge in vitro was pH cycling (11.8%); in situ was sucrose + biofilm (6.2%); and in vivo, biofilm (6.2%). The most used erosive cycle was 4× per day in in vitro studies (20.4%) and 1× in vivo (2.1%). A positive effect was observed in prevention (41.9%) and treatment (24.7%) studies. Conclusion: TIF4 has shown a positive effect in prevention and therapeutic treatments for dental caries and erosion.