Ehrlichia canis (Jaboticabal strain) induces the expression of TNF-α in leukocytes and splenocytes of experimentally infected dogs

Canine ehrlichiosis is caused by the bacterium Ehrlichia canis and is characterized by a systemic febrile disease of unknown pathogenesis. This study evaluated the expression of cytokines TNF-α, IL-10, IFN-γ, in splenic cells and blood leukocytes during the acute phase of ehrlichiosis and after trea...

Full description

Saved in:
Bibliographic Details
Published in:Revista brasileira de parasitologia veterinaria 2011-01, Vol.20 (1), p.71-74
Main Authors: Faria, Joice Lara Maia, Munhoz, Thiago Demarchi, João, Carolina Franchi, Vargas-Hernández, Giovanny, André, Marcos Rogério, Pereira, Wanderson Adriano Biscola, Machado, Rosângela Zacarias, Tinucci-Costa, Mirela
Format: Article
Language:English
Subjects:
Animals
Dog Diseases - immunology
Dog Diseases - microbiology
Dogs
Ehrlichia canis - classification
Ehrlichia canis - physiology
Ehrlichiosis - immunology
Ehrlichiosis - veterinary
Leukocytes - immunology
PARASITOLOGY
Spleen - cytology
Spleen - immunology
Tumor Necrosis Factor-alpha - biosynthesis
VETERINARY SCIENCES
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Canine ehrlichiosis is caused by the bacterium Ehrlichia canis and is characterized by a systemic febrile disease of unknown pathogenesis. This study evaluated the expression of cytokines TNF-α, IL-10, IFN-γ, in splenic cells and blood leukocytes during the acute phase of ehrlichiosis and after treatment with doxycycline hyclate in dogs experimentally infected with the E. canis Jaboticabal strain. The study results showed a significant expression of TNF-α 18 days post-inoculation, reducing by approximately 70% after treatment. There was a unique peak of expression of IL-10 and IFN-γ 18 and 30 days post-inoculation, respectively. This study suggests that TNF-α plays a role in the pathogenesis of the acute phase of canine ehrlichiosis and that treatment with doxycycline hyclate reduces the systemic effects of this cytokine, possibly by reducing or eliminating parasitemia.
ISSN:1984-2961
1984-2961
DOI:10.1590/S1984-29612011000100015