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A Brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters Sertoli cell secretion and mitochondrial activity

Our objective was to investigate whether the pulp and paper mill industry effluent could affect the testis and Sertoli cells in a fast exposure period. For this, the present study was carried out in immature rats at 10-day-old. Testis treated in vitro with 4% effluent for 1 h presented changes in en...

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Published in:Animal reproduction 2020-01, Vol.17 (2), p.e20190116-e20190116
Main Authors: Oliveira, Vanessa Staldoni de, Castro, Allisson Jhonatan Gomes, Domingues, Juliana Tonietto, Souza, Ariane Zamoner Pacheco de, Scheffer, Débora da Luz, Latini, Alexandra, Soares, Carlos Henrique Lemos, Van Der Kraak, Glen, Silva, Fátima Regina Mena Barreto
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creator Oliveira, Vanessa Staldoni de
Castro, Allisson Jhonatan Gomes
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Latini, Alexandra
Soares, Carlos Henrique Lemos
Van Der Kraak, Glen
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description Our objective was to investigate whether the pulp and paper mill industry effluent could affect the testis and Sertoli cells in a fast exposure period. For this, the present study was carried out in immature rats at 10-day-old. Testis treated in vitro with 4% effluent for 1 h presented changes in energy metabolism in terms of a decrease in lactate content and glucose uptake. Elevation in GSH content, as an antioxidant defense mechanism, was also detected. Sertoli cells treated with 4% effluent for 1 hour showed alterations in the mitochondrial metabolism that favor the decoupling of oxidative phosphorylation and the generation of oxygen reactive species and also a time and concentration-dependent delay secretion of acidic vesicles. Our results showed that pollutants present in the pulp and paper mill effluents, in a short time of exposure, are capable of inducing alterations in important metabolic functions in the testis and in Sertoli cells that are crucial for the correct progression of spermatogenesis and fertility.
doi_str_mv 10.1590/1984-3143-ar2019-0116
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subjects BIOTECHNOLOGY & APPLIED MICROBIOLOGY
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title A Brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters Sertoli cell secretion and mitochondrial activity
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