Vitamin D Deficiency and Cardiovascular Diseases

Abstract Vitamin D is considered a steroid hormone with a broad spectrum of action in the human body. Its action arises from the binding of its active metabolite (1α,25-dihydroxyvitamin D) to its receptor (VDR), which is present throughout the body, including vascular smooth muscle cells and cardiom...

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Bibliographic Details
Published in:International journal of cardiovascular sciences 2018-08, Vol.31 (4), p.422-432
Main Authors: Jorge, Antonio José Lagoeiro, Cordeiro, Jamerson Reis, Rosa, Maria Luiza Garcia, Bianchi, Diego Braga Campos
Format: Article
Language:English
Subjects:
CARDIAC & CARDIOVASCULAR SYSTEMS
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Summary:Abstract Vitamin D is considered a steroid hormone with a broad spectrum of action in the human body. Its action arises from the binding of its active metabolite (1α,25-dihydroxyvitamin D) to its receptor (VDR), which is present throughout the body, including vascular smooth muscle cells and cardiomyocytes. Initially, vitamin D deficiency was related only to changes in the musculoskeletal system, but in recent years, researchers have demonstrated its relationship with several pathologies related to other systems, such as cardiovascular diseases. The objective of this study is to review vitamin D’s pathophysiology, describe its relationship with cardiovascular diseases based on the most recent publications, and highlight the results of vitamin supplementation in the prevention of such pathologies.
ISSN:2359-5647
2359-5647
DOI:10.5935/2359-4802.20180025