Enhancing sensitivity of a whispering gallery mode biosensorby subwavelength confinement

The authors demonstrate enhanced sensitivity of a spherical whispering gallery mode biosensor (WGMB) by confining orbiting light near the surface using a subwavelength (sub- λ ) high refractive index layer on a fluorine doped silica microsphere (radius R ∼ 200 μ m ). Their experiments at a free spac...

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Bibliographic Details
Published in:Applied physics letters 2006-11, Vol.89 (22), p.223901-223901-3
Main Authors: Gaathon, O., Culic-Viskota, J., Mihnev, M., Teraoka, I., Arnold, S.
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Summary:The authors demonstrate enhanced sensitivity of a spherical whispering gallery mode biosensor (WGMB) by confining orbiting light near the surface using a subwavelength (sub- λ ) high refractive index layer on a fluorine doped silica microsphere (radius R ∼ 200 μ m ). Their experiments at a free space wavelength λ ∼ 1310 nm show that the frequency shift sensitivity by changing the external refractive index is increased by more than 700% by adding a 340 nm thick polystyrene layer. This advance is expected to move the WGMB well into the lead as the most sensitive method for unlabeled biosensing.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.2397017