Detection of template binding to molecularly imprinted polymersby Raman microspectroscopy

We report on sensitive and specific detection and quantification of a template in a molecularly imprinted polymer (MIP) using Raman microspectroscopy. The β -blocking drug S -propranolol and its enantiomer, R -propranolol, were used as target molecules since the selectivity of this MIP is well estab...

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Bibliographic Details
Published in:Applied physics letters 2009-05, Vol.94 (19), p.194103-194103-3
Main Authors: Kantarovich, Keren, Belmont, Anne-Sophie, Haupt, Karsten, Bar, Ilana, Gheber, Levi A.
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Summary:We report on sensitive and specific detection and quantification of a template in a molecularly imprinted polymer (MIP) using Raman microspectroscopy. The β -blocking drug S -propranolol and its enantiomer, R -propranolol, were used as target molecules since the selectivity of this MIP is well established and serves as an appropriate validation standard. Specific peaks originating in the template were identified in the Raman spectrum, allowing quantification of bound target molecule. We demonstrate that label-free monitoring can be achieved from volumes as small as 1   μ m 3 of MIP, based on a single identifying peak.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.3132061