Protein/carbon nanotubes interaction: The effect of carboxylic groupson conformational and conductance changes

Detailed understanding of interaction between biomolecules and single-walled carbon nanotubes (SWCNTs) is important in the design and applications of biosensors that employ SWCNTs for transduction of the analytes response. Reciprocal interactions of SWCNT with bovine serum albumin are investigated h...

Full description

Saved in:
Bibliographic Details
Published in:Applied physics letters 2009-08, Vol.95 (7), p.073704-073704-3
Main Authors: Mahendra Wijaya, I. Putu, Gandhi, Sonu, Ju Nie, Tey, Wangoo, Nishima, Rodriguez, Isabel, Shekhawat, G., Suri, C. Raman, Mhaisalkar, Subodh G.
Format: Article
Language:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Detailed understanding of interaction between biomolecules and single-walled carbon nanotubes (SWCNTs) is important in the design and applications of biosensors that employ SWCNTs for transduction of the analytes response. Reciprocal interactions of SWCNT with bovine serum albumin are investigated here with pristine and carboxylated nanotubes. Carboxylic functionalization was found to inflict a deeper change on protein conformation, than their pristine counterparts, accompanied with a change in nanotube conductance. This observation has significant implications for biosensors in highlighting the need to take into account the surface functionalization state of the active materials.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.3211328