Contrast-enhanced digital mammography and other techniques based on image subtraction

This article reviews research done by the author and collaborators in the general area of subtraction techniques applied to radiological images, in particular in contrast-enhanced digital mammography (CEDM). Main achievements have been the development and phantom validation of a general formalism to...

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Bibliographic Details
Main Author: Brandan, María-Ester
Format: Conference Proceeding
Language:English
Subjects:
Biomarkers
Correlation analysis
Dependence
Digital imaging
Image contrast
Image enhancement
Iodine
Mammography
Subtraction
Online Access:Get full text
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Summary:This article reviews research done by the author and collaborators in the general area of subtraction techniques applied to radiological images, in particular in contrast-enhanced digital mammography (CEDM). Main achievements have been the development and phantom validation of a general formalism to subtract images using dual-energy or temporal modalities, the proposal of a hybrid modality called dual-energy temporal, and of a matrix-based compensation for the energy dependence of the anatomical background for dual-energy subtraction. This has been validated with non-homogenous phantom measurements and applied to clinical images using iodine-based contrast medium. Results from the clinical study have led the group to study the correlation between CEDM image parameters and angiogenic biomarkers in a murine breast cancer model. Clinical CEDM subtracted images have been subjected to textural analysis.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.4954122