Radiobromine production, isolation and radiosynthesis for the development of a novel prostate cancer radiotherapeutic agent

The radioactive isotopes of bromine accessible with low energy medical cyclotrons have unique potential for diagnostic and radiotherapeutic nuclear medicine applications. These include bromine-76 (t1/2 = 16 h) for positron emission tomography and bromine-77 (t1/2 = 57 h) for Auger radionuclide thera...

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Bibliographic Details
Main Authors: Ellison, Paul A., Graves, Stephen A., Murali, Dhanabalan, De Jesus, Onofre T., Barnhart, Todd E., Thomadsen, Bruce R., Speer, Tod, Nickles, Robert J.
Format: Conference Proceeding
Language:English
Subjects:
Augers
Bromine
Bromine isotopes
Cyclotrons
Diagnostic software
Diagnostic systems
Distillation
Liquid cooling
Nuclear medicine
Positron emission
Prostate
Proton irradiation
Radiation therapy
Radiochemistry
Radioisotopes
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Summary:The radioactive isotopes of bromine accessible with low energy medical cyclotrons have unique potential for diagnostic and radiotherapeutic nuclear medicine applications. These include bromine-76 (t1/2 = 16 h) for positron emission tomography and bromine-77 (t1/2 = 57 h) for Auger radionuclide therapy. Methods are presented to synthesize NiSe discs from elemental starting materials for proton irradiation in a 4π water cooling target configuration. Radiobromide was isolated from the irradiated NiSe material by dry distillation and used to radiolabel 7α-BrDHT for investigation as an Androgen-receptor-targeted theranostic radiopharmaceutical.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.4983538