Radiobromine production, isolation and radiosynthesis for the development of a novel prostate cancer radiotherapeutic agent

The radioactive isotopes of bromine accessible with low energy medical cyclotrons have unique potential for diagnostic and radiotherapeutic nuclear medicine applications. These include bromine-76 (t1/2 = 16 h) for positron emission tomography and bromine-77 (t1/2 = 57 h) for Auger radionuclide thera...

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Main Authors: Ellison, Paul A., Graves, Stephen A., Murali, Dhanabalan, De Jesus, Onofre T., Barnhart, Todd E., Thomadsen, Bruce R., Speer, Tod, Nickles, Robert J.
Format: Conference Proceeding
Language:English
Subjects:
Augers
Bromine
Bromine isotopes
Cyclotrons
Diagnostic software
Diagnostic systems
Distillation
Liquid cooling
Nuclear medicine
Positron emission
Prostate
Proton irradiation
Radiation therapy
Radiochemistry
Radioisotopes
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cited_by cdi_FETCH-LOGICAL-c293t-4f6ca2e89fc4d3de199c4e437bde7d0027246e8daa91d023fa3c1d758d5c7bf73
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container_title
container_volume 1845
creator Ellison, Paul A.
Graves, Stephen A.
Murali, Dhanabalan
De Jesus, Onofre T.
Barnhart, Todd E.
Thomadsen, Bruce R.
Speer, Tod
Nickles, Robert J.
description The radioactive isotopes of bromine accessible with low energy medical cyclotrons have unique potential for diagnostic and radiotherapeutic nuclear medicine applications. These include bromine-76 (t1/2 = 16 h) for positron emission tomography and bromine-77 (t1/2 = 57 h) for Auger radionuclide therapy. Methods are presented to synthesize NiSe discs from elemental starting materials for proton irradiation in a 4π water cooling target configuration. Radiobromide was isolated from the irradiated NiSe material by dry distillation and used to radiolabel 7α-BrDHT for investigation as an Androgen-receptor-targeted theranostic radiopharmaceutical.
doi_str_mv 10.1063/1.4983538
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source American Institute of Physics:Jisc Collections:Transitional Journals Agreement 2021-23 (Reading list)
subjects Augers
Bromine
Bromine isotopes
Cyclotrons
Diagnostic software
Diagnostic systems
Distillation
Liquid cooling
Nuclear medicine
Positron emission
Prostate
Proton irradiation
Radiation therapy
Radiochemistry
Radioisotopes
title Radiobromine production, isolation and radiosynthesis for the development of a novel prostate cancer radiotherapeutic agent
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