The model of drugs distribution dynamics in biological tissue

The dose distribution by Neutron Capture Therapy follows the distribution of 10B in the tissue. The modern models of pharmacokinetics of drugs describe the processes occurring in conditioned “chambers” (blood-organ-tumor), but fail to describe the spatial distribution of the drug in the tumor and in...

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Bibliographic Details
Main Authors: Ginevskij, D. A., Izhevskij, P. V., Sheino, I. N.
Format: Conference Proceeding
Language:English
Subjects:
Conditioning
Drugs
Inhomogeneous media
Mathematical models
Nuclear capture
Pharmacology
Random processes
Spatial distribution
Tumors
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Summary:The dose distribution by Neutron Capture Therapy follows the distribution of 10B in the tissue. The modern models of pharmacokinetics of drugs describe the processes occurring in conditioned “chambers” (blood-organ-tumor), but fail to describe the spatial distribution of the drug in the tumor and in normal tissue. The mathematical model of the spatial distribution dynamics of drugs in the tissue, depending on the concentration of the drug in the blood, was developed. The modeling method is the representation of the biological structure in the form of a randomly inhomogeneous medium in which the 10B distribution occurs. The parameters of the model, which cannot be determined rigorously in the experiment, are taken as the quantities subject to the laws of the unconnected random processes. The estimates of 10B distribution preparations in the tumor and healthy tissue, inside/outside the cells, are obtained.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.5001601