Cytotoxic activities of sea cucumber (Bohadschia argus) extract against T47D cells

Sea cucumber extract has potential health benefits including antitumor and use in the treatment of chronic inflammatory diseases. The purpose of the present study was to investigate cytotoxic activity of sea cucumber extract on human breast cancer cell line T47D. This study used WST-assay to analyze...

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Bibliographic Details
Main Authors: Souhaly, Jantje Wiliem, Rahayu, Sri
Format: Conference Proceeding
Language:English
Subjects:
Cytotoxicity
Invertebrates
Methanol
Toxicity
Online Access:Get full text
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Summary:Sea cucumber extract has potential health benefits including antitumor and use in the treatment of chronic inflammatory diseases. The purpose of the present study was to investigate cytotoxic activity of sea cucumber extract on human breast cancer cell line T47D. This study used WST-assay to analyze cytotoxicity of sea cucumber using two types of extraction, water extraction and methanol extraction. The treatment concentrations in this study were control, 50 µg/mL, 100 µg/mL, 250 µg/mL and 500 µg/mL. The results showed that sea cucumber extracts have potential to inhibit growth of the T47D cell line, with optimum concentration of water extraction at 480 µg/mL and 145 µg/mL for methanol extraction. So it can be concluded that extract of sea cucumber (Bohadschia argus) has potential as an anticancer therapy as it inhibits growth of T47D cells.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.5061917