Synthesis and evaluation antibacterial activity of phosphate buffer solution (pH 7.4) - soluble acylated chitosan derivative

The N-maleoyl chitosan (MCS) is a chemically modified derivative of the biopolymer chitosan that was synthesized through acylation reaction between chitosan and maleic anhydride acid. The resulting MCS was characterized by FT-IR spectroscopy and its antibacterial activity was evaluated against Staph...

Full description

Saved in:
Bibliographic Details
Main Authors: Pasaribu, Subur P., Kaban, Jamaran, Ginting, Mimpin, Sinaga, Kasmirul Ramlan
Format: Conference Proceeding
Language:English
Subjects:
Acylation
Anhydrides
Bacteria
Biomedical materials
Biopolymers
Buffer solutions
Chemical synthesis
Chitosan
Drug delivery systems
E coli
Fourier transforms
Hydrogels
Infrared spectroscopy
Maleic anhydride
Organic chemistry
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The N-maleoyl chitosan (MCS) is a chemically modified derivative of the biopolymer chitosan that was synthesized through acylation reaction between chitosan and maleic anhydride acid. The resulting MCS was characterized by FT-IR spectroscopy and its antibacterial activity was evaluated against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) bacteria by Agar diffusion method on the Muller Hinton Agar. MCS was soluble in a phosphate buffer solution (PBS, pH 7.4) with a concentration of 2 % (w/v), and did not show any antibacterial activity against both test bacteria. However, with the formation of chitosan derivative soluble in the physiological medium of PBS, pH 7.4 will expand its utilization in the formation of hydrogels for biomedical applications such as drug delivery.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.5082430