Physicochemical characterization of ribavirin with spectroscopy and molecular modeling

The applicability of UV spectroscopy to the quantitative determination of ribavirin in aqueous solutions was demonstrated. The existence of a third conformational form of ribavirin was found, and the optimization of three ribavirin conformers was performed using the nonempirical Kohn–Sham method. It...

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Bibliographic Details
Main Authors: Kienskaya, K. I., Bobrov, M. F., Kusmaev, A. M., Krivitskaya, A. V., Koldaeva, T. U., Sardushkin, M. V., Ibragimova, R. R., Belova, I. A., Kukharenko, A. V., Mazitova, G. T., Ermolenko, Y. V., Zavyalova, O. V.
Format: Conference Proceeding
Language:English
Subjects:
Aqueous solutions
Optimization
Spectrum analysis
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Summary:The applicability of UV spectroscopy to the quantitative determination of ribavirin in aqueous solutions was demonstrated. The existence of a third conformational form of ribavirin was found, and the optimization of three ribavirin conformers was performed using the nonempirical Kohn–Sham method. It was found that, regardless of the confirmation of ribavirin molecules, the absorption maximum of its aqueous solution corresponds to 206 nm.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0018459