Genetic and epigenetic aspects of class III malocclusion with mandibular prognathism phenotypes

Malocclusion is a deviation of a normal occlusal relationship, inflicting a notable aesthetic concern and functional hindrance on the affected individuals. Class III malocclusion is a type of malocclusion with several defined phenotypes, such as mandibular prognathism and macrognathia. The early con...

Full description

Saved in:
Bibliographic Details
Main Authors: Zabrina, Stephanie, Ramadhanti, Jazaldi, Fadli, Gultom, Ferry Pergamus, Auerkari, Elza Ibrahim
Format: Conference Proceeding
Language:English
Subjects:
Epigenetics
Etiology
Morphology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Malocclusion is a deviation of a normal occlusal relationship, inflicting a notable aesthetic concern and functional hindrance on the affected individuals. Class III malocclusion is a type of malocclusion with several defined phenotypes, such as mandibular prognathism and macrognathia. The early concept of Class III malocclusion is thought to be governed heavily by genetic factors. However, major advancements in research discover that it is somewhat multifactorial, involving the interaction of both genetic and epigenetic factors at some levels. Modern genomic studies on the genetic mechanisms of facial variations show signs of future success in helping to understand the etiology of malocclusion and variation of dentofacial morphology. This knowledge gives helpful insights on the limits of what orthodontic treatments could achieve, which in turn influences orthodontist in diagnosing the severity of Class III malocclusion, choosing the appropriate treatment timing, planning the proper treatment plans, as well as preventing relapse from happening.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0047282