Integrating hyperelastic constitutive models in natural biopolymer for healing patch technology

• Main Authors: Nazali, Nur Nabila Mohd, Manan, Nor Fazli Adull, Mahmud, Jamaluddin, Abdullah, Abdul Halim
• Format: Conference Proceeding
• Language: English
• Subjects: Biodegradability; Biomechanics; Biomedical materials; Biopolymers; Composition; Constitutive equations; Constitutive models; Constitutive relationships; Curve fitting; Distilled water; Energy theory; Mathematical models; Mechanical properties; Parameters; Reagents; Tensile tests; Wound healing
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/5.0049146

In biomaterial science, different forms of healing patch were invented on the current market to minimize wound area infections. The healing patch may also be known as a temporary covering for wounds. The general requirement of wound dressing are optimum absorption rate, healing time reduction and fitted with an antibacterial agent. The additional parameters for this project are mechanical properties. A balanced composition of the new wound-healing material between basic mechanical and biomechanical properties is difficult to find. Thus, if it posed as a potential healing patch, the reach centered more on the essential mechanical and biomechanical properties of the natural biopolymer. The technique that emphasizes the estimation of models of hyper elastic material to match with the experimental data. This work was therefore introduced with the comparison of the material to separate the samples into three groups. Second, the three sample sets are subjected to a uniaxial tensile test to obtain raw mechanical data. The theory of large-scale deformation based on hyperelastic constitutive equations and Stress-Strain Energy Theory was established for numerical phases. Finally, the curve fit between the experimental results, the hyperelastic models Ogden and Mooney-Rivlin were compiled. Most of the curve fit that was presented followed the patterns but due to different material composition or polymer bonding, there are minor variations. The best texture to pose as an artificial skin or healing patch is set B based on the three sample sets (Set A, Set B, Set C). Set B samples consist of gelatine, glycerin, distilled water, and aloe vera. The highest material constants obtained for the Ogden hyperelastic model were α=1.8792 µ=0.1881 MPa from Set B with a tensile speed of 500 mm / min respectively. Mooney-Rivlin’s highest content constants obtained were C1=0.0746 C2=0.1294 from Set C, respectively at a tensile speed of 500 mm/min. The Ogden model is the correct guide for the development of healing patches, based on curve fitting figures. Overall, the acceptable composition of the healing patch was established, the differences in parameters between hyperelastic models were measured, and the effect of the basic mechanical and biomechanical properties were explained. The misuse of animal or human skin for experimental artificial skin purposes could be reduced as a matter of meaning. In addition, in the medical field, the latest technologies for biodegradable and renewab